This region stretches in a belt from north to south along the broad valley of the Olifants River. Again, summers are relatively warm compared to some of South Africa's other wine areas and rainfall is relatively low. Soils vary from sandy to red clay loams.

With careful canopy management which ensures grapes are shaded by the vines' leaves combined with modern winemaking techniques, the Olifants River is rapidly emerging as an important source of good, value-for-money wines. The Olifants River region incorporates the wards of Vredendal, Spruitdrift, Lutzville Valley and Koekenaap, as well as the cooler, higher-altitude wards of Cederberg and Piekenierskloof.